From what i have heard 64 bit seems to be fairly compatible. Plus you can use more ram than 32 bit and its more stable. Ive also heard its faster.
Here is a compatibility test using some older programs. It did quite well:
7-zip Works Link
AMD Opteron™ Processor PowerNow! Driver 1.2.2.0 - 1.2.2.1 Untested Untested as yet. Link
AnyDVD 5.0 BETA Works mixture 32 bit software, 64 bit drivers. Link
Asus Probe III 64-bit ?? Works downloaded from asus
Avast 4 Works Tested by Shivan Link
avast! antivirus 4.6 Works Link
Cakewalk Sonar x64 ? Untested Untested as yet. Link
Chronicles of Riddick: Escape from Butcher Bay ? Works Works like a charm, seems a little faster then 32-bit Link
CINEBENCH ? Works The applications themself work fully, only where it comes to the use of external libraries and codecs limitations apply. Link
CINEMA 4D R9 Works The applications themself work fully, only where it comes to the use of external libraries and codecs limitations apply. Link
CloneCD 5.2 BETA Works mixture 32 bit software, 64 bit drivers. Link
CloneDVD 2.8 BETA Works mixture 32 bit software, 64 bit drivers. Link
CommTraffic v2.1 2.1 Works Untested as yet. Link
CommView for WiFi v5.0 5 Works Untested as yet. Link
CommView v5.0 5 Works Untested as yet. Link
Daemon Tools 4.01HE Works Works like a charm Link
DigiSecret Lite v2.0 2 Works Untested as yet. Link
DigiSecret Pro v2.0 2 Works Untested as yet. Link
Essential NetTools v3.2 3.2 Works Untested as yet. Link
Etrust anti-virus software. Works Link
Far Cry x64 Works Tested by Richard Henderson Link
Firefox 20050123 Works 64 bit Firefox 20050501 works fine, using normal firefox extensions fine. Also need to add your own shortcuts as currently isn't using an installer (thanx to Tarby and John Stanley) Link
Firestreamer-RM Works Backup Software Link
Logitech SetPoint unknown Untested Untested as yet. Link
NOD32 anti-virus 2.51.8 Works Untested as yet. Link
NOD32 v2.50.20 beta 2.50.20 Beta Works Reported working, has some issues. i.e. context menu items are not available. IMON only works with the 32 bit version of IE. Link
O&O Defrag V8.0 Professional Edition 8 (x64 edition) Works The standard 32-bit won't work Link
O&O Defrag V8.0 Server Edition 8 Untested Untested as yet. Link
PeerGuardian 2 2 Untested Untested as yet. Link
PeerGuardian 2 2 Works
PHP 4.3.11 ISAPI/Interpreter Modules 4.3.11 Untested Untested as yet.
Process Explorer (x64 version) Works reports an error when starting: 'The version of Dbghelp.dll configured does not support the Microsoft Symbol Server' http://www.microsoft.com/whdc/devtools/debugging/default.mspx After clicking ok, the program starts.
Process Explorer 9.03 9.03 Untested Untested as yet. Link
Realtech OpenGL extension viewer 2.16 Works
Shadow Ops: Red mercury ? Untested Untested as yet.
Sisoft Sandra 2005 Untested Untested as yet. Link
SmartWhois v4.0 4 Works Untested as yet. Link
Software995 ?? Works Link
Speedfan 4.23 Untested Untested as yet. Link
Speedfan 4.25 Works No problems Link
Squeez 5 (compression program) 5 Works Works perfectly, with 64-bit context menus Link
Sun Java Virtual Machine RC1 Works
Sun JRE 5.0 Update 5 5.0 Works "Windows AMD64 Platform - J2SE(TM) Runtime Environment 5.0 Update 5" Link
Symantec Antivirus ?? Works Reported working.
Sysinternals Filemon 6.13 Untested Untested as yet. Link
Sysinternals Regmon 6.12 Untested Untested as yet. Link
Tiny firewall pro 6.5 Works
TweakUI 6? Works Seems to be an Old IA64 version, dated 2001, adjusted for AMD64 (coming from M$ Beta site) Link
Unreal Tournament 2004 2004 Works
Virtual CloneDrive 5.1 BETA Not Working mixture 32 bit software, 64 bit drivers. Link
VirtualDub 1.6.4 Works
WindowBlinds 4.51 Works smoother transition from theme to theme than native windows themes (thanx to Grant) Link
Windows BestCrypt 7 Works Encryption software Link
Winimage 7.0 Works
Winimage 7.0e.7009 Works works well and the free virtual CD works without any configuaration for uncompressed ISO and BIN.